PAC1

Product Name: PAC1
CAS No.: 315183-21-2
Chemical Name: PAC1
Synonyms: PAC1;DUSP2;PAC1-R;CS-243;PAC1（b）;ADCYAP1R1;PAC-1,PAC1;PAC-1 10MG;PAC 1, >=98%;Pac1 receptor
CBNumber: CB71075505
Molecular Formula: C23H28N4O2
Formula Weight: 392.49
MOL File: 315183-21-2.mol

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PAC1 Property

Density: 1.14
storage temp.: Store at +4°C
solubility: DMSO: ≥10mg/mL
form: solid
pka: 8.82±0.40(Predicted)
color: white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-36/37/38-50/53
Safety Statements: 26-36/37-60-61
RIDADR: UN 3077
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0115
Product name: PAC-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: P0115
Product name: PAC-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $384
Updated: 2024/03/01

Sigma-Aldrich

Product number: SAB1301755
Product name: ANTI-DUSP2 (C-TERM) antibody produced in rabbit
Purity: IgG fraction of antiserum, buffered aqueous solution
Packaging: 400μL
Price: $461
Updated: 2023/01/07

Cayman Chemical

Product number: 10009317
Product name: PAC-1
Purity: ≥98%
Packaging: 25mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 10009317
Product name: PAC-1
Purity: ≥98%
Packaging: 50mg
Price: $201
Updated: 2024/03/01

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PAC1 Chemical Properties,Usage,Production

Description

PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3

Uses

PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.

Biological Activity

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).

storage

+4°C

References

1) Putt et al. (2006), Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy; Nat. Chem. Biol., 2 543 2) Peterson et al. (2009), PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition; J. Mol. Biol., 388 144 3) Bolham et al. (2016), Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with diverse Chemotherapeutics; ACS Cent. Sci., 2 545

PAC1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PAC1 Suppliers

Canada 1 China 104 Germany 1 India 1 Ukraine 1 United Kingdom 3 United States 22 Global 133

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

ApexBio Technology LLC

Tel: +1-832-696-8203
Fax: +1-832-641-3177
Email: info@apexbt.com
Country: United States
ProdList: 477
Advantage: 60

HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10658
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

315183-21-2, PAC1Related Search:

AC-VDVAD-PNA Z-VAD-FMK Bortezomib LY2109761 Paclitaxel Obatoclax mesilate 1-(3,4-DICHLOROBENZYL)-1H-INDOLE-2,3-DIONE Ruxolitinib AC-VEID-AMC Z-ASP-2,6-DICHLOROBENZOYLOXYMETHYLKETONE Z-YVAD-AFC ALPHA-(TRICHLOROMETHYL)-4-PYRIDINEETHANOL AC-VDVAD-CHO AC-DEVD-AFC AC-DEVD-CHO AC-LEHD-AFC AC-LEU-GLU-THR-ASP-AFC PAC1

PAC1

4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide

PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide

4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

PAC-1,PAC1

Procaspase activating coMpound 1

(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide

4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1

PAC 1 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

(4-Benzylpiperazino)acetic acid (3-allyl-2-hyroxybenzylidene)hydrazide

1-Piperazineacetic acid, 2-(phenylmethyl)-,[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hyrrazide

ADCYAP1R1

Pac1 receptor

Pac1 receptors

PAC1-R

PACAP receptor 1

ANTI-DUSP2 (C-TERM) antibody produced in rabbit

Dual specificity protein phosphatase 2

Dual specificity protein phosphatase PAC-1

DUSP2

Anti-DUSP2 (C-terminal) antibody produced in rabbit

PAC 1, >=98%

PAC-1 10MG

PAC-1, 98%, a procaspase-3 activatior

CS-243

PAC 1 - Procaspase activating compound 1

1-Piperazineacetic acid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide

PAC-1 >=98% (HPLC)

PAC1 USP/EP/BP

PAC-1 (VO-100)

N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide

PAC1（b）

N'-(3-Allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide

315183-21-2

Inhibitor

Inhibitors